GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1116547 | 1 | rs11741963 | chr5:112702773 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.05 | 5.53E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs2036402 | 1 | rs11746128 | chr5:156421250 | TIMD4 | chr5:156346293-156390266:- | -0.17 | -4.82 | 1.65E-6 | Hypertriglyceridemia |
| BRCA | cis | rs11603691 | 1 | rs117497302 | chr11:57009807 | PRG2 | chr11:57151267-57191532:- | -0.24 | -3.89 | 0.000107 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11750568 | 1 | rs11750568 | chr5:178535713 | ZNF354C | chr5:178487607-178507689:+ | -0.11 | -3.77 | 0.000174 | Height |
| BRCA | cis | rs1116547 | 1 | rs11750945 | chr5:112710755 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.11 | 4.24E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs12206610 | 1 | rs11751207 | chr6:166018383 | PDE10A | chr6:165740779-166075584:- | 0.19 | 4.3 | 1.86E-5 | Spherical equivalent (joint main effects and education interaction) |
| BRCA | cis | rs10484434 | 1 | rs11751732 | chr6:26044064 | HIST1H3B | chr6:26031817-26032288:- | 0.15 | 3.47 | 0.000538 | HIV-1 viral setpoint |
| BRCA | cis | rs1853207 | 1 | rs117530406 | chr10:96397876 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.4 | 8.04E-8 | Blood metabolite levels |
| BRCA | cis | rs943466 | 1 | rs11753083 | chr6:33761111 | C6orf125 | chr6:33662057-33679504:- | 0.11 | 3.42 | 0.000651 | Body mass index |
| BRCA | cis | rs943466 | 1 | rs11753083 | chr6:33761111 | LEMD2 | chr6:33738991-33756906:- | 0.17 | 5.22 | 2.15E-7 | Body mass index |
| BRCA | cis | rs11753937 | 1 | rs11753937 | chr6:133663589 | EYA4 | chr6:133561736-133853257:+ | -0.15 | -4.09 | 4.64E-5 | Response to angiotensin II receptor blocker therapy |
| BRCA | cis | rs943466 | 1 | rs11754690 | chr6:33744157 | C6orf125 | chr6:33662057-33679504:- | 0.11 | 3.56 | 0.000385 | Body mass index |
| BRCA | cis | rs943466 | 1 | rs11754690 | chr6:33744157 | LEMD2 | chr6:33738991-33756906:- | 0.18 | 5.49 | 5.0E-8 | Body mass index |
| BRCA | cis | rs11758351 | 1 | rs11754744 | chr6:26202605 | HIST1H3E | chr6:26224427-26226589:+ | 0.36 | 7.01 | 4.11E-12 | Renal underexcretion gout;Gout |
| BRCA | cis | rs11758351 | 1 | rs11755210 | chr6:26202768 | HIST1H3E | chr6:26224427-26226589:+ | 0.36 | 7.01 | 4.11E-12 | Renal underexcretion gout;Gout |